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  • br and taxanes br only br BMI br Abbreviations Pts

    2020-08-18


    and taxanes
    only
    BMI
    Abbreviations: Pts patients, HR hormone receptors, BMI body mass index, PVI peritumoral vascular invasion
    * Chi-square test comparing proportions between HR and BMI categories. p-Value were calculated excluding undefined or unknown values.
    Table 2. Univariate analysis of variables associated with distant disease-free survival and 3-years distant disease-free survival in HER2+ early breast cancer (eBC) patients
    Variable Distant disease-free survival 3y Distant disease-free survival
    HR-positive vs HR-negative
    stage I vs stage II-III
    Negative vs positive
    ACCEPTED MANUSCRIPT
    No vs yes
    Negative vs positive
    No vs yes
    Antracyclines+Taxanes vs others
    Abbreviations: CI confidence interval, HR hormone receptors, BMI body mass index, PVI peritumoral vascular invasion
    Table 3. Multivariate Cox regression analysis of variables associated with distant disease-free survival and 3-years distant disease-free survival in HER2+ early breast cancer (eBC) patients
    Variable Distant disease-free survival 3y Distant disease-free survival
    stage III vs stage I-II
    Positive vs negative
    Antracyclines+Taxanes vs
    others
    Abbreviations: CI confidence interval, HR hormone receptors, BMI body mass index
    ACCEPTED MANUSCRIPT
    Figures
    Figure 1. Distant disease-free survival of HER2+ eBC patients based on hormone ω-Muricholic Acid status (median follow up:
    ACCEPTED MANUSCRIPT
    Figure 2. 3-Years distant disease-free survival of HER2+ eBC patients based on hormone receptor status
    ACCEPTED MANUSCRIPT
    Figure 3. 3-Years distant disease-free survival of HER2+ eBC patients stratified by hormonal receptor status and BMI index. Four categories have been identified (HR+/BMI<25; HR+/BMI≥25; HR-/BMI<25; HR-/BMI≥25).
    Contents lists available at ScienceDirect
    Cancer Epidemiology
    journal homepage: www.elsevier.com/locate/canep
    Body mass index and the risk of head and neck cancer in the Chinese T
    population
    Yuji Chena, Yuan-Chin Amy Leea, Shuang Lia, Qian Lib, Chien-Jen Chenc,d, Wan-Lun Hsuc, Pen-Jen Loue, Cairong Zhuf, Jian Pang, Hongbing Shenh, Hongxia Mah, Lin Caii, Baochang Hei, Yu Wangj,k, Xiaoyan Zhouk,l, Qinghai Jij,k, Baosen Zhoum, Wei Wum, Jie Man, Daisuke Kawakitaa,o, Paolo Boffettap, Zuo-Feng Zhangq, Min Dair, Mia Hashibea,
    a Division of Public Health, Department of Family and Preventive Medicine, University of Utah School of Medicine and Huntsman Cancer Institute, Salt Lake City, UT, USA
    b Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA
    c Genomics Research Center, Academia Sinica, Taipei, Taiwan
    d Graduate Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan
    e Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan
    f Department of Epidemiology and Biostatistics, West China School of Public Health, Sichuan University, Sichuan, China
    g Department of Oral Surgery, West China Hospital of Stomatology, Sichuan University, Sichuan, China
    h Department of Epidemiology and Biostatistics, Jiangsu key lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, China
    i Department of Epidemiology and Biostatistics, School of Public Health, Fujian Medical University, Fujian, China
    j Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China
    k Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
    l Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China
    m Department of Epidemiology, School of Public Health, China Medical University, Liaoning, China
    n Department of Head & Neck Oncology, Henan Cancer Hospital, Henan, China
    o Department of Otorhinolaryngology, Head and Neck Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    p Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York City, NY, USA
    q Department of Epidemiology and Center for Environmental Genomics, UCLA Fielding School of Public Health, Los Angeles, CA, USA
    r National Office of Cancer Prevention & Control Cancer Institute & Hospital, and Chinese Academy of Medical Sciences, Beijing, China
    Keywords:
    BMI
    Head and neck cancer risk
    East Asia
    Objective: To investigate potential associations between body mass index (BMI) and head and neck cancer (HNC) risk in an East Asian population.
    Methods: We conducted a one gene one polypeptide hypothesis hospital-based multicenter case-control study in East Asia including 921 cases and 806 controls. We estimated the odds ratios (ORs) and 95% confidence intervals (95% CI) for HNC risks by using logistic regression, adjusting on potential confounders.